The Mighty Fungus ...
Natures Pharmacy
Provailen uses almost 4000 years of
knowledge to create a unique and
Powerful 3 in 1 arthritis and joint relief
formula.
The first recorded usage for the main ingredient is about 4000 years ago, but it was just recently that we now have the technology to extract the true potential of the reishi fungi spore. By tapping into nature's proven, powerful pharmacy we now have a formula to bring you true relief from the pain and suffering of arthritis.
You might be surprised but it’s true. Fungi are rich in powerful chemicals and are regularly used in some of the most famous drugs and medicines on the planet.
The past 50 years has seen several examples of major advancements in medicine that came from fungi and yeasts. Of the over 14,000 varieties of fungus, around 3,000 are edible, at least 700 have known natural medicinal properties, and less than 1.0% are recognized as poisonous.
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The Most Powerful Medicinal
Drugs On The Planet
Take antibiotics such as penicillin, tetracycline and aureomycin for instance. They were developed from fungi or mold spores and caused a complete revolution in health care treatment. Cyclosporin, a powerful immunosuppressive drug, is another example.
Codeine and Morphine the powerful analgesics and Papavarine, a smooth muscle relaxant, all come from the plant Papaver somniferum . . . the humble Poppy.
Quinine, a successful antimalarial drug, is manufactured from Quisqualis indica, also known as the Chinese honeysuckle.
But what about Reishi fungi specifically?
Reishi fungi has six species classed as medicinal which have been reported to contain around 200 active elements that have specific medicinal properties.
Let’s look at the main components of Ganoderma Reishi and how they can benefit you:
Polysaccharides
Decreases allergies, enhances the immune system and significantly improves autoimmune diseases such as Rheumatoid Arthritis, Ankylosing Spondylitis, SLE (Systemic Lupus Erythematosus), chronic kidney inflammation, dry eye syndrome, Sicca syndrome, scleroderma (skin hardening), epilepsy, Myasthenia gravis and Type 1 Diabetes.
Regarding anti-inflammatory properties in general, an Indian study in 2003 demonstrated that in cases of acute or chronic edema, Reishi decreased inflammation by 56% and 60% respectively. (1)
An earlier American study (1993) had already shown that, water extracts of G. pentaphyllum and G. lucidum [Reishi] were found to possess significant anti-inflammatory activity. (2) In the references are seven additional papers listed which all conclude that Reishi (Ganoderma lucidum) possesses potent anti-inflammatory qualities. (3,4,5,6,7,8,9)
In 2006, Kenneth Blum et al. published findings to show both the effectiveness and safety of using Reishi extract for “joint health,” providing “clinical evidence” to back up their claim. (10)
In the same year, a Chinese study by Xi Bao et al. concluded that Reishi along with another medicinal herbal remedy used across China appeared to have a “beneficial immunomodulatory effect” on arthritis. (11)
Exactly how Reishi achieves its beneficial action on arthritis may have been stumbled upon by Ho et al. in 2007 (12) when they discovered that GL-PP [Ganoderma lucidum polysaccharide peptide] actually helped to significantly reduce one of the causative agents of rheumatoid arthritis known as RASF, short for “Rheumatoid Arthritis Synovial Fibroblasts.”
Several papers summarizing positive results in the use of Reishi against arthritis have been published. (13,14,15) One states that Reishi compares favorably to prednisone, but without side effects. (16)
A separate study found that Reishi supplementing, helps to balance the side effects of prednisolone, including protein in the urine and cell toxicity. (19) (Prednisolone is the active compound of prednisone, which gets broken down by the liver and converted to prednisolone.)
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References
(1) Lakshmi, B., T.A. Ajith, N. Sheena, N. Gunapalan & K.K. Janardhanan, 2003. "Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum occurring in South India." Teratog Carcinog Mutagen Suppl 1:85-97.
(2) Lin, J.M., C.C. Lin, H.F. Chiu, J.J. Yang & S.G. Lee, 1993. "Evaluation of the anti-inflammatory and liver-protective effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in rats." Am J Chin Med. 21(1):59-69.
(3) Han, M.D., E.S. Lee, Y.K. Kim, 1998. "Production of nitric oxide in raw 264.7 macrophages treated with ganoderan, the beta glucan of Ganoderma lucidum." Korean Journal of Mycology 26:246-55.
(4) Zhu, M., Q. Chang, L.K. Wond, F.S. Chong and R.C. Li, 1999. "Triterpene antioxidants from Ganoderma lucidum." Phytotherapy Research 13, 529-531.
(5) Ukai, S., T. Kiho, C. Hira, I. Kuruma and Y. Tanaka, 1983. "Polysaccharides in fungi. XIV. Anti-inflammatory effect of the polysaccharides from the fruitbodies of several fungi." Journal of Pharmacobiodynamics Dec; 6(12): 983-90.
(6) Ko, H-H., H. Chi-Feng, J-P. Wang & C-N. Lin, 2008. "Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae." Phytochemistry Volume 69, Issue 1, January, Pages 234-239.
(7) Akihisa, T., Y. Nakamura, M. Tagata, H. Tokuda, K. Yasukawa, E. Uchiyama, T. Suzuki & Y. Kimura, 2007. "Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum." Chem Biodivers. Feb;4(2):224-31.
(8) Hong, K.J., D.M. Dunn, C.L. Shen & B.C. Pence, 2004. "Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells." Phytother Res. Sep;18(9):768-70.
(9) Liu, Y.H., C.F. Tsai, M.C. Kao, Y.L. Lai & J.J. Tsai, 2003. "Effectiveness of Dp2 nasal therapy for Dp2- induced airway inflammation in mice: using oral Ganoderma lucidum as an immunomodulator." J Microbiol Immunol Infect. Dec;36(4):236-42.
(10) Blum, K., B. Meshkin & B.W. Downs, 2006. "DNA based customized nutr aceutical "gene therapy" utilizing a genoscore: A hypothesized paradigm shift of a novel approach to the diagnosis, stratification, prognosis and treatment of inflammatory processes in the human." Medical Hypotheses, Volume 66, Issue 5, Pages 1008-1018
(11) Xi Bao Y, Kwok Wong C, Kwok Ming Li E, Shan Tam L, Chung Leung P, Bing Yin Y & Wai Kei Lam C., 2006. "Immunomodulatory effects of lingzhi and san-miao-san supplementation on patients with rheumatoid arthritis." Immunopharmacol Immunotoxicol. 28(2):197-200.
(12) Ho, Y.W., J.S. Yeung, P.K. Chiu, W.M. Tang, Z.B. Lin, R.Y. Man & C.S. Lau, 2007. "Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast." Mol Cell Biochem. Jul;301(1-2):173-9. Epub 2007 Jan 12.
(13) Stavinoha, W.B., J.T. Slama & S.T. Weintraub, 1996. "The anti-inflammatory activity of Ganoderma lucidum 6.1" pp. 193-6 in Ganoderma lucidum, A Medicinal Mushroom, Ganoderma lucidum Ganoderma, Polyporaceae and others. Oriental Tradition, Cultivation, Breeding, Chemistry, Biochemistry and Utilization of Ganoderma lucidum" ed. by T. Mizuno. Il-Yang Pharm Co.
(14)Mizuno, T. & B.K. Kim, 1996. "A Medicinal Mushroom, Ganoderma lucidum." Il-Yang Pharm Co., Seoul, Korea
(15)Lam, F.F.Y., I.W.M. Ko, E.S.K. Ng, L.S. Tam, P.C. Leung & E.K.M. Li, 2008. "Analgesic and anti-arthritic effects of Lingzhi and San Miao San supplementation in a rat model of arthritis induced by Freund's complete adjuvant." Journal of Ethnopharmacology In Press, Corrected Proof, Available online 30 July 2008
(16)Stavinoha, W.B., S. Weintraub, T. Opham, A. Colorado, R. Opieda & J. Slama, 1990. "Study of the anti-inflammatory activity of Ganoderma lucidum." Proceedings from the Academic/Industry Conference (AIJC), August 18-20, Sapporo, Japan.Mizuno96
